Tg(Neurod2-Smo*A1)199Jols
Transgene Detail

Summary

• Symbol: Tg(Neurod2-Smo*A1)199Jols
• Name: transgene insertion 199, James M Olson
• MGI ID: MGI:3830738
• Synonyms: ND2:SmoA1, SmoA1, SmoA1:199
• Transgene: Tg(Neurod2-Smo*A1)199Jols Location: unknown Genetic Position: Chr14, cytoband C1
• Alliance: Tg(Neurod2-Smo*A1)199Jols page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Neurod2-Smo*A1)199Jols expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Smo (MGI:108075)

• Mutation details: The ND2:SmoA1 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA1 (W539L), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Several lines were generated (lines 199, 193, 234, 255 and 201) with varying levels of expression (30-, 45-, 36-, 2- and 3-fold, respectively, relative to wild0type expression). (J:93861)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800
• All: 51 reference(s)