Tg(Pbsn-Ar*E231G)7353Ng
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Ar*E231G)7353Ng
• Name: transgene insertion 7353, Norman M Greenberg
• MGI ID: MGI:3831171
• Synonyms: AR-E231G, PB-AR(E231G), PB-AR^E231G
• Transgene: Tg(Pbsn-Ar*E231G)7353Ng Location: unknown
• Alliance: Tg(Pbsn-Ar*E231G)7353Ng page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-Ar*E231G)7353Ng expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Ar (24208)

  Ar	(MGI:88064)

• Mutation details: A transgenic construct containing the mutant mouse androgen receptor (Ar), E231G, under the control of the minimal -426/+28 rat probasin promoter, a rabbit beta-globin sequence fragment, a bovine growth hormone polyadenylation site sequence and an N-terminal hemagglutinin (HA) epitope tag was injected into fertilized FVB/N mouse eggs. Seven lines were generated and founder line 7353 was established. (J:96117)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-Ar*E231G)7353Ng

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96117 Han G, et al., Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1151-6
• All: 3 reference(s)