Tg(SMN2)11Tro
Transgene Detail

Summary

• Symbol: Tg(SMN2)11Tro
• Name: transgene insertion 11, Thierry Bordet
• MGI ID: MGI:3832059
• Synonyms: SMN2(N11)
• Transgene: Tg(SMN2)11Tro Location: unknown
• Alliance: Tg(SMN2)11Tro page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SMN2)11Tro expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: A 35.5 kb Ba mHI genomic fragment encoding the human SMN2 promoter and gene (derived from genomic clone PAC215P15) was injected into fertilized FVB/N mouse oocytes. Transgenic SMN2 mice from founder line 11, which contains 1 copy of the transgene, were established. (J:144852)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Smn1^tm1Msd/Smn1^tm1Msd Tg(SMN2)11Tro/Tg(SMN2)11Tro	B6.Cg-Smn1^tm1Msd Tg(SMN2)11Tro
cx2	Smn1^tm1Msd/Smn1^tm1Msd Tg(SMN2)11Tro/0	B6.Cg-Smn1^tm1Msd Tg(SMN2)11Tro
cx3	Smn1^tm1Msd/Smn1^+ Tg(SMN2)11Tro/Tg(SMN2)11Tro	B6.Cg-Smn1^tm1Msd Tg(SMN2)11Tro
cx4	Smn1^tm1Msd/Smn1^tm1Msd Tg(SMN2)11Tro/0	B6.Cg-Tg(SMN2)11Tro Smn1^tm1Msd/J
cx5	Smn1^tm1Msd/Smn1^tm1Msd Tg(SMN2)11Tro/Tg(SMN2)11Tro	B6.Cg-Tg(SMN2)11Tro Smn1^tm1Msd/J
cx6  Disease Model	Smn1^tm1Msd/Smn1^tm1Msd Tg(SMN2)11Tro/0 Tg(SMN2)46Tro/0	B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1^tm1Msd/J
tg7	Tg(SMN2)11Tro/Tg(SMN2)11Tro	involves: C57BL/6 * FVB/N

Phenotypes:

Affected Systems	cx1	cx2	cx3	cx4	cx5	cx6	tg7
show or hide all annotated terms
behavior/neurological						√
behavior/neurological phenotype						N
abnormal gait						√
positive geotaxis						√
increased thermal nociceptive threshold						√
craniofacial						√
abnormal outer ear morphology						√
growth/size/body	√				√	√
abnormal outer ear morphology						√
decreased birth body size	√
decreased body weight	√
slow postnatal weight gain						√
weight loss					√
abnormal embryonic growth/weight/body size	√
hearing/vestibular/ear						√
abnormal outer ear morphology						√
homeostasis/metabolism						N
homeostasis/metabolism phenotype						N
limbs/digits/tail						√
abnormal autopod morphology						√
abnormal tail morphology						√
mortality/aging	√	√		√	√	√
decreased survivor rate						√
postnatal lethality, complete penetrance	√				√
neonatal lethality, incomplete penetrance	√
postnatal lethality, incomplete penetrance						√
embryonic lethality		√		√
muscle						√
abnormal skeletal muscle fiber morphology						√
muscular atrophy						√
abnormal muscle electrophysiology						√
progressive muscle weakness						√
nervous system			N			√	N
nervous system phenotype			N				N
decreased motor neuron number						√
abnormal synaptic bouton morphology						√
abnormal neuromuscular synapse morphology						√
abnormal phrenic nerve morphology						√
abnormal sciatic nerve morphology						√
axon degeneration						√
respiratory system						√
abnormal respiration						√
apnea						√
abnormal respiratory mechanics						√
decreased pulmonary ventilation						√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx6
Werdnig-Hoffmann disease IDs Werdnig-Hoffmann disease       DOID:13137 ICD10CM:G12.0 ICD9CM:335.0 MESH:D014897 NCI:C98670 OMIM:253300 UMLS_CUI:C0043116 Close	√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:144852 Bordet T, Generation of an SMN2 transgene (line 11). MGI Direct Data Submission. 2009
• All: 2 reference(s)