Tg(Thy1-MAPT*V337M)1Godt
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*V337M)1Godt
• Name: transgene insertion 1, Michel Goedert
• MGI ID: MGI:3832877
• Synonyms: TauV337M, Tg(Thy1-MAPT*V337M)1Migo
• Transgene: Tg(Thy1-MAPT*V337M)1Godt Location: unknown
• Alliance: Tg(Thy1-MAPT*V337M)1Godt page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*V337M)1Godt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The promoter was used to drive brain-specific expression of a cDNA that encodes the longest three-repeat human isoform with nucleotide substitutions resulting in the amino acid substitution of methionine for valine at position 337 (V337M). This mutation was originally identified in patients with frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17). No line information was given. (J:143018)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143018 Lambourne SL, et al., Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age. Hum Mol Genet. 2007 Jul 15;16(14):1708-19
• All: 1 reference(s)