Tg(Thy1-SERPINI1*G392E)333Icka
Transgene Detail

Summary

• Symbol: Tg(Thy1-SERPINI1*G392E)333Icka
• Name: transgene insertion 333, Ichiro Kato
• MGI ID: MGI:3833390
• Synonyms: G392E-Tg
• Transgene: Tg(Thy1-SERPINI1*G392E)333Icka Location: unknown
• Alliance: Tg(Thy1-SERPINI1*G392E)333Icka page

Transgene origin

• Strain of Origin: (C57BL x DBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SERPINI1*G392E)333Icka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SERPINI1 (5274)

  Serpini1

  (MGI:1194506)

• Mutation details: The promoter was used to drive neuron-specific expression of the human cDNA containing nucleotide substitutions that result in the amino acid substitution of glutamic acid for glycine at position 392 (G392E). This mutation was originally discovered in patients with familial encephalopathy with neuroserpin inclusion bodies (FENIB). Three lines were created (333, 42, 115) with line 333 expressing at much higher levels than lines 42 and 115. (J:144649)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144649 Takasawa A, et al., Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J Biol Chem. 2008 Dec 19;283(51):35606-13
• All: 1 reference(s)