Tgfbr3l MGI Mouse Gene Detail - MGI:3833469 - transforming growth factor, beta receptor III-like

Symbol

Tgfbr3l
Name

transforming growth factor, beta receptor III-like
Synonyms

Gm14378, LOC100039590

Feature Type

protein coding gene
IDs

MGI:3833469
NCBI Gene: 100044509
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:4298214-4301423 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 1.99 cM

SNPs within 2kb

113 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3833469	protein coding gene	Chr8:4297994-4301528 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033329	protein coding gene	Chr8:1233599-1236808 (+)
A/J	MGP_AJ_G0033310	protein coding gene	Chr8:1182899-1186108 (+)
AKR/J	MGP_AKRJ_G0033241	protein coding gene	Chr8:1218104-1221313 (+)
BALB/cJ	MGP_BALBcJ_G0033310	protein coding gene	Chr8:1235990-1239190 (+)
C3H/HeJ	MGP_C3HHeJ_G0033024	protein coding gene	Chr8:1227964-1231173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033822	protein coding gene	Chr8:1272847-1276056 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030794	protein coding gene	Chr8:1057279-1060972 (+)
CAST/EiJ	MGP_CASTEiJ_G0032348	protein coding gene	Chr8:1111753-1114964 (+)
CBA/J	MGP_CBAJ_G0032997	protein coding gene	Chr8:1312127-1315336 (+)
DBA/2J	MGP_DBA2J_G0033151	protein coding gene	Chr8:1143175-1146384 (+)
FVB/NJ	MGP_FVBNJ_G0033098	protein coding gene	Chr8:1182493-1185702 (+)
LP/J	MGP_LPJ_G0033245	protein coding gene	Chr8:1153737-1156946 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033133	protein coding gene	Chr8:1287375-1290584 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033839	protein coding gene	Chr8:1201740-1204940 (+)
PWK/PhJ	MGP_PWKPhJ_G0032059	protein coding gene	Chr8:1107735-1110944 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031902	protein coding gene	Chr8:1122976-1126219 (+)
WSB/EiJ	MGP_WSBEiJ_G0032462	protein coding gene	Chr8:1181281-1184481 (+)

Human Ortholog

TGFBR3L, transforming growth factor beta receptor 3 like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TGFBR3L, transforming growth factor beta receptor 3 like
Synonyms

GEMP, TGFR-3L
Links

HGNC:44152

NCBI Gene ID: 100507588

neXtProt AC: NX_H3BV60

UniProt: H3BV60
Chr Location

chr19:7914830-7919097 (+) GRCh38

MGI Vertebrate Homology

Tgfbr3l stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TGFBR3L
Gene Tree

Tgfbr3l

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased liter size, oocyte numbers, and serum follicle stimulating hormone levels.

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

5
cDNA Data

1
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS57603.1

Ensembl

ENSMUSG00000089736 (Evidence)
NCBI Gene

100044509

			Length	Strain/Species	Flank
genomic	ENSMUSG00000089736	Ensembl Gene Model \| MGI Sequence Detail	3210	C57BL/6J	± kb
transcript	ENSMUST00000110993	Ensembl \| MGI Sequence Detail	1075	Not Applicable
polypeptide	ENSMUSP00000106621	Ensembl \| MGI Sequence Detail	297	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032046 transforming growth factor-beta receptor type 3-like protein

(term hierarchy)
InterPro Domains

IPR001507 Zona pellucida domain

IPR042235 Zona pellucida, ZP-C domain

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All nucleic 2

cDNA 1

Primer pair 1

Summaries

All 15

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 3
Earliest

J:298990 Sah RK, et al., Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tgfbr3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76110	Chr8:4298188-4298219 (+)	-10 bp
Tssr76111	Chr8:4298223-4298241 (+)	18 bp
Tssr76112	Chr8:4298248-4298267 (+)	44 bp
Tssr76113	Chr8:4299457-4299459 (+)	1,244 bp
Tssr76114	Chr8:4300307-4300319 (+)	2,099 bp
Tssr76115	Chr8:4300433-4300444 (+)	2,225 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24