Tg(Ly6a-BCR/ABL1)IS1BIsg
Transgene Detail

Summary

• Symbol: Tg(Ly6a-BCR/ABL1)IS1BIsg
• Name: transgene insertion IS1B, Isidro Sanchez-Garcia
• MGI ID: MGI:3834463
• Synonyms: IS1B
• Transgene: Tg(Ly6a-BCR/ABL1)IS1BIsg Location: unknown
• Alliance: Tg(Ly6a-BCR/ABL1)IS1BIsg page

Transgene origin

• Strain of Origin: (CBA x C57BL/6J)

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ly6a-BCR/ABL1)IS1BIsg expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABL1 (25)

  Abl1	(MGI:87859)

  human

  BCR (613)

  Bcr	(MGI:88141)

• Mutation details: The promoter was used to drive hematopoietic stem cell-specific expression of a human BCR-ABL1p210 fusion. Two lines were created (IS1A and IS1B) that exhibit similar phenotypes. (J:144382)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144382 Perez-Caro M, et al., Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J. 2009 Jan 7;28(1):8-20
• All: 3 reference(s)