Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg
Transgene Detail

Summary

• Symbol: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg
• Name: transgene insertion IS9A, Isidro Sanchez-Garcia
• MGI ID: MGI:3834479
• Synonyms: IS9A
• Transgene: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg Location: unknown
• Alliance: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg page

Transgene origin

• Strain of Origin: (CBA x C57BL/6J)

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABL1 (25)

  Abl1	(MGI:87859)

  human

  BCR (613)

  Bcr	(MGI:88141)

• Mutation details: The promoter was used to drive hematopoietic stem cell-specific expression of a human thymidine kinase and BCR-ABL1p210 fusion separated by an IRES. One line was created (IS9A). (J:144382)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144382 Perez-Caro M, et al., Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J. 2009 Jan 7;28(1):8-20
• All: 1 reference(s)