Tg(SFTPC-EML4/ALK)502-4Hima
Transgene Detail

Summary

• Symbol: Tg(SFTPC-EML4/ALK)502-4Hima
• Name: transgene insertion 502-4, Hiroyuki Mano
• MGI ID: MGI:3834680
• Synonyms: EML4-ALK
• Transgene: Tg(SFTPC-EML4/ALK)502-4Hima Location: unknown
• Alliance: Tg(SFTPC-EML4/ALK)502-4Hima page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-EML4/ALK)502-4Hima expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

  human

  EML4 (27436)

  Eml4	(MGI:1926048)

• Mutation details: The human SFTPC promoter was used to drive lung-specific expression of a flag-tagged human fusion generated in human non-small-cell lung cancer due to recurrent chromosome inversion, inv(2)(p21p23). Two lines were created (502-4 and 501-3) that exhibit identical tumor-forming activity. Line 502-4 was selected as the representative line. Line 502-4 carried 30 copies of the transgene. (J:142679)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(SFTPC-EML4/ALK)502-4Hima

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142679 Soda M, et al., A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19893-7
• All: 2 reference(s)