Tg(Prnp*D177N*M128V)A21Rchi
Transgene Detail

Summary

• Symbol: Tg(Prnp*D177N*M128V)A21Rchi
• Name: transgene insertion A21, Roberto Chiesa
• MGI ID: MGI:3836986
• Synonyms: CJD-A21, moPrP D177N/V128, Tg(CJD), Tg(CJD-A21)
• Transgene: Tg(Prnp*D177N*M128V)A21Rchi Location: unknown
• Alliance: Tg(Prnp*D177N*M128V)A21Rchi page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*D177N*M128V)A21Rchi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: Site directed mutagenesis was used to generate a murine Prnp gene homologous to the D178N/V129 human variants linked to Creutzfeldt-Jakob disease. Five founder lines were created with this line containing 22 copies of the transgene. Transgenic protein levels in hemizygote brain were similar to endogenous protein levels, with about 50% of transgenic protein being insoluble. (J:142098)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:142098 Dossena S, et al., Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron. 2008 Nov 26;60(4):598-609
• All: 5 reference(s)