Tg(Myh7-RARA/lacZ)30Mcco
Transgene Detail

Summary

• Symbol: Tg(Myh7-RARA/lacZ)30Mcco
• Name: transgene insertion 30, Melissa C Colbert
• MGI ID: MGI:3838149
• Synonyms: beta-MyHC-hRARalpha-CB
• Transgene: Tg(Myh7-RARA/lacZ)30Mcco Location: unknown
• Alliance: Tg(Myh7-RARA/lacZ)30Mcco page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Myh7-RARA/lacZ)30Mcco expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: The mouse promoter was used to drive cardiac-specific expression of a human cDNA truncated at amino acid 448 and fused in frame via a collagen linker to lacZ. This truncation and fusion produces a constitutively active form. Two lines (30 and 32) were created. Line 30 has 12 copies of the transgene. (J:146424)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146424 Colbert MC, et al., Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. J Clin Invest. 1997 Oct 15;100(8):1958-68
• All: 2 reference(s)