Tg(Myh6-MYL2*D166V)1Dsc
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYL2*D166V)1Dsc
• Name: transgene insertion 1, Danuta Szczesna-Cordary
• MGI ID: MGI:3838172
• Synonyms: Tg-D166V
• Transgene: Tg(Myh6-MYL2*D166V)1Dsc Location: unknown
• Alliance: Tg(Myh6-MYL2*D166V)1Dsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYL2*D166V)1Dsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYL2 (4633)

  Myl2	(MGI:97272)

• Mutation details: The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third was used to drive cardiac-specific expression of a mutated human cDNA derived from patient with familial hypertrophic cardiomyopathy that contains an amino acid substitution of valine for aspartic acid at position 166 (D166V). No line information was given. (J:146091)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146091 Kerrick WG, et al., Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice. FASEB J. 2009 Mar;23(3):855-65
• All: 9 reference(s)