Tg(Thy1-MAPT*P301S)2541Godt
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*P301S)2541Godt
• Name: transgene insertion 2541, Michel Goedert
• MGI ID: MGI:3778191
• Synonyms: TauP301S, Tg2541
• Transgene: Tg(Thy1-MAPT*P301S)2541Godt Location: unknown
• Alliance: Tg(Thy1-MAPT*P301S)2541Godt page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*P301S)2541Godt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  Expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats (0N4R) - in which proline is replaced by serine at amino acid position 301 of the protein (P301S).

• Mutation details: The neuron-specific promoter elements of the mouse Thy1 gene drive expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats (0N4R) - in which proline is replaced by serine at amino acid position 301 of the protein (P301S). Immunoblot analysis demonstrates the presence of human tau at approximately twice the level of the combined endogenous mouse tau proteins in brains and spinal cords of 5-6 month old homozygous transgenic mice. (J:108870)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic lines were established from three founder mice. The data reported were obtained using mice of line 2541. (J:108870)

References

• Original: J:108870 Allen B, et al., Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51
• All: 44 reference(s)