Tg(Ckm-IGF1R*K1003R)1Dlr
Transgene Detail

Summary

• Symbol: Tg(Ckm-IGF1R*K1003R)1Dlr
• Name: transgene marker 1, Derek LeRoith
• MGI ID: MGI:3842765
• Synonyms: MCK-KR-hIGF-IR, MKR
• Transgene: Tg(Ckm-IGF1R*K1003R)1Dlr Location: unknown
• Alliance: Tg(Ckm-IGF1R*K1003R)1Dlr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-IGF1R*K1003R)1Dlr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1R (3480)

  Igf1r

  (MGI:96433)

• Mutation details: The promoter, enhancer 1, exon 1, first intron/enchancer 2, and first 16 base pairs of exon 2 were used to drive muscle-specific expression of a dominant-negative human gene with nucleotide substitutions that result in the amino acid substitution of arginine for lysine at position 1003 (K1003R). Five lines were created with around 12 copies of the transgene. No line names were given. (J:71205)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:71205 Fernandez AM, et al., Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev. 2001 Aug 1;15(15):1926-34
• All: 35 reference(s)