Tg(Camk2a-UBB*)3413-1Fwvl
Transgene Detail

Summary

• Symbol: Tg(Camk2a-UBB*)3413-1Fwvl
• Name: transgene insertion 3413-1, FW van Leeuwen
• MGI ID: MGI:3843483
• Synonyms: UBB+1 3413, UBB⁺¹ 3413
• Transgene: Tg(Camk2a-UBB*)3413-1Fwvl Location: unknown
• Alliance: Tg(Camk2a-UBB*)3413-1Fwvl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-UBB*)3413-1Fwvl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  UBB (7314)

  Ubb	(MGI:98888)

• Mutation details: A transgenic construct containing cDNA encoding the mutant human ubiquitin B, UBB+1 sequence (in the +1 reading frame), under the direction of the mouse Camk2a (calcium/calmodulin-dependent protein kinase II alpha) promoter was injected into fertilized C57BL/6 mouse eggs. Founder line 3413-1 with 13 copies of the transgene was subsequently established. mRNA levels for UBB+1 are 49% of endogenous Ubb mRNA levels. (J:147938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:147938 Fischer DF, et al., Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiol Aging. 2009 Jun;30(6):847-63
• All: 7 reference(s)