Tg(ACTB-TNFRSF6B)754Jwu
Transgene Detail

Summary

• Symbol: Tg(ACTB-TNFRSF6B)754Jwu
• Name: transgene insertion 754 Jiangping Wu
• MGI ID: MGI:3843671
• Synonyms: DcR3 Tg
• Transgene: Tg(ACTB-TNFRSF6B)754Jwu Location: unknown
• Alliance: Tg(ACTB-TNFRSF6B)754Jwu page

Transgene origin

• Strain of Origin: C3H x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-TNFRSF6B)754Jwu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	TNFRSF6B (8771)

• Tg(ACTB-TNFRSF6B)754Jwu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTB (60)

  Actb	(MGI:87904)

• Mutation details: The construct consists of human full length Dcr3 (TNFRSF6B) cDNA flanked by human beta actin promoter and beta actin poly(A) signal. The construct was injected into fertilized eggs from C3H x C57BL/6 mice. Line 754 was established and analyzed further. (J:148162)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Line 17139 exhibits a phenotype similar to Line 754, including lymphadenopathy, pathologies in skin, kidney and liver and a shortened lifespan in females.

References

• Original: J:148162 Han B, et al., Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. Arthritis Rheum. 2007 Nov;56(11):3748-58
• All: 3 reference(s)