Tg(PTH-CCND1)PC2Anar
Transgene Detail

Summary

• Symbol: Tg(PTH-CCND1)PC2Anar
• Name: transgene insertion PC2, Andrew Arnold
• MGI ID: MGI:3844257
• Synonyms: PC2, Tg(PTH-CCND1)2Anar
• Transgene: Tg(PTH-CCND1)PC2Anar Location: unknown
• Alliance: Tg(PTH-CCND1)PC2Anar page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PTH-CCND1)PC2Anar expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CCND1 (595)

  Ccnd1

  (MGI:88313)

• Mutation details: 5.2 kb of the upstream regulatory region the human PTH gene was used to drive long range tissue specific expression of the full-length 16 kb human cyclin D1 gene in conjunction with its own promoter elements for basal expression. This fusion mimics an inversion found in some human parathyroid adenomas. Three lines were created (1, 2, and 4 with 3, 11, and 15 copies of the transgene, respectively). Line 2 was selected as the representative line. (J:69423)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:69423 Imanishi Y, et al., Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice. J Clin Invest. 2001 May;107(9):1093-102
• All: 5 reference(s)