Tg(CAG-PKD2)#Hwl
Transgene Detail

Summary

• Symbol: Tg(CAG-PKD2)#Hwl
• Name: transgene insertion, Han-Woong Lee
• MGI ID: MGI:3844550
• Transgene: Tg(CAG-PKD2)#Hwl Location: unknown
• Alliance: Tg(CAG-PKD2)#Hwl page

Cystic kidneys in Tg(CAG-PKD2)#Hwl/? mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-PKD2)#Hwl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PKD2 (5311)

  Pkd2	(MGI:1099818)

• Mutation details: The chicken beta actin promoter and cytomegalovirus immediate early enhancer (pCAGGS) drive expression of a human PKD2 cDNA. Four lines (C, D, E, F) were generated all containing multiple copies of the transgene. Semi quantitative RT-PCR and western blot analysis confirmed expression of the transgene in the kidneys. This record is for data pooled from multiple lines. (J:148377)

Schematic of the Tg(CAG-PKD2)#Hwl transgene

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:148377 Park EY, et al., Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. J Biol Chem. 2009 Mar 13;284(11):7214-22
• All: 3 reference(s)