Tg(CD2-Stat6*V625A*T626A)78Mhk
Transgene Detail

Summary

• Symbol: Tg(CD2-Stat6*V625A*T626A)78Mhk
• Name: transgene insertion 78, Mark H Kaplan
• MGI ID: MGI:3845883
• Synonyms: Stat6VT, StatVT
• Transgene: Tg(CD2-Stat6*V625A*T626A)78Mhk Location: unknown
• Alliance: Tg(CD2-Stat6*V625A*T626A)78Mhk page

Transgene origin

• Strain of Origin: C3H

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Stat6*V625A*T626A)78Mhk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STAT6 (6778)

  Stat6

  (MGI:103034)

• Mutation details: This transgene expresses the human STAT6 gene, with codons V625 and T626 mutated to express alanine and a C-terminal FLAG tag added, under transcriptional control of the CD2 locus control region. This promoter restricted expression of the transgene primarily to B and T lymphocytes. In addition to line 78, founder line 24 was also established. (J:133480)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Ocular Atopic Dermatitis J:230018.

References

• Original: J:133480 Bruns HA, et al., Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol. 2003 Apr 1;170(7):3478-87
• All: 15 reference(s)