Tg(Pcp2-FMR1*)1Dln
Transgene Detail

Summary

• Symbol: Tg(Pcp2-FMR1*)1Dln
• Name: transgene insertion 1, David L Nelson
• MGI ID: MGI:3848937
• Synonyms: L7CGG90Fmr1
• Transgene: Tg(Pcp2-FMR1*)1Dln Location: unknown
• Alliance: Tg(Pcp2-FMR1*)1Dln page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-FMR1*)1Dln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FMR1 (2332)

  Fmr1	(MGI:95564)

• Mutation details: The mouse promoter human gene was used to drive Purkinje cell specific expression of the flag-tagged human cDNA preceded by a 90 CGG repeat. Seven lines were created (no line numbers given). (J:149320)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149320 Hashem V, et al., Ectopic expression of CGG containing mRNA is neurotoxic in mammals. Hum Mol Genet. 2009 Jul 1;18(13):2443-51
• All: 3 reference(s)