Tg(Prnp-FTL*)4Ruvi
Transgene Detail

Summary

• Symbol: Tg(Prnp-FTL*)4Ruvi
• Name: transgene insertion 4, Ruben Vidal
• MGI ID: MGI:3848965
• Synonyms: FTL-Tg4, MoPrP-FTL498-499InsTC
• Transgene: Tg(Prnp-FTL*)4Ruvi Location: unknown
• Alliance: Tg(Prnp-FTL*)4Ruvi page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-FTL*)4Ruvi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FTL (2512)

  Ftl1	(MGI:95589)
  Ftl1-ps2	(MGI:5434102)
  Ftl2-ps	(MGI:95590)

• Mutation details: The mouse promoter was used to drive brain and heart specific expression of the human cDNA with TC insertions at the cDNA positions 498 and 499, respectively. This insertion leads to a frame-shift that alters the last 9 amino acids of the C-terminus and adds 16 additional amino acids. Four lines were created (lines 1, 2, 3, and 4) with 40 to 50, 5 to 10, 1 to 5, and 1 to 5 copies of the transgene, respectively. Line 4 was used for subsequent studies. (J:131053)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131053 Vidal R, et al., Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice. J Neurosci. 2008 Jan 2;28(1):60-7
• All: 3 reference(s)