Tg(Lck-Tal1)4709Led
Transgene Detail

Summary

• Symbol: Tg(Lck-Tal1)4709Led
• Name: transgene insertion 4709, Philip Leder
• MGI ID: MGI:3528080
• Synonyms: 4709, lck-tal1, tal-1(4709)
• Transgene: Tg(Lck-Tal1)4709Led Location: unknown
• Alliance: Tg(Lck-Tal1)4709Led page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Tal1)4709Led expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tal1 (MGI:98480)

• Mutation details: A Tal1 cDNA cloned from a mouse erythroleukemic cell line was cloned downstream of the mouse Lck promoter. 3' splice and polyA sequences were derived from the human growth hormone gene. Transgene expression in the thymus was high after birth and continued at low levels throughout adulthood. Six lines were created (4709, 4719, 4722, 4723, 4726, and 4727) and line 4709 was selected as the representative line. (J:36076)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Lck-Tal1)4709Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:36076 Kelliher MA, et al., Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J. 1996 Oct 1;15(19):5160-6
• All: 6 reference(s)