Tg(Lck-Tnfsf14)24Yxf
Transgene Detail

Summary

• Symbol: Tg(Lck-Tnfsf14)24Yxf
• Name: transgene insertion 24, Yang-Xin Fu
• MGI ID: MGI:3849832
• Synonyms: Tg(Lck-LIGHT)
• Transgene: Tg(Lck-Tnfsf14)24Yxf Location: unknown
• Alliance: Tg(Lck-Tnfsf14)24Yxf page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Tnfsf14)24Yxf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnfsf14 (MGI:1355317)

• Mutation details: Tnfsf14 coding sequence was driven by the proximal Lck promoter and human CD2 enhancer with human growth hormone gene (polyadenylation site) included downstream. Lines 24 and 27 in a C57BL/6 background were selected for further investigation with similar phenotypes observed in both lines. Expression in lymphocytes was confirmed by flow cytometry analysis of lymphocytes. (J:129951)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129951 Wang J, et al., The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest. 2001 Dec;108(12):1771-80
• All: 4 reference(s)