Tg(Myh6-BRUNOL4*)10Coop
Transgene Detail

Summary

• Symbol: Tg(Myh6-BRUNOL4*)10Coop
• Name: transgene insertion 10, Thomas A Cooper
• MGI ID: MGI:3850088
• Synonyms: MHC-CELFdelta, MHC-CELFdelta-10
• Transgene: Tg(Myh6-BRUNOL4*)10Coop Location: unknown
• Alliance: Tg(Myh6-BRUNOL4*)10Coop page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-BRUNOL4*)10Coop expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CELF4 (56853)

  Celf4

  (MGI:1932407)

  Expresses a truncated form of human CELF4

• Mutation details: A truncated form of the human CELF4 (BRUNOL4), which acts as a dominant negative protein in cultured cells, was expressed in the heart under the control of an alpha-myosin heavy chain promoter. In addition to line 10, lines 11 and 574 were also generated. Line 11 was susequently lost. (J:99369)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99369 Ladd AN, et al., Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy. Mol Cell Biol. 2005 Jul;25(14):6267-78
• All: 4 reference(s)