Tg(Scn1a*)RH9Aesc
Transgene Detail

Summary

• Symbol: Tg(Scn1a*)RH9Aesc
• Name: transgene insertion RH9, Andrew Escayg
• MGI ID: MGI:3851210
• Synonyms: Scn1a^Tg-RH9
• Transgene: Tg(Scn1a*)RH9Aesc Location: unknown
• Alliance: Tg(Scn1a*)RH9Aesc page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scn1a*)RH9Aesc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Scn1a (MGI:98246)	R1648H substitution

• Mutation details: A BAC (clone 259E13) of size 187 kb containing mouse genomic sequence extending from 115 kb upstream of the Scn1a translation start site to 3 kb downstream from the polyA termination signal was modified to add a FLAG tag, an E954Q substitution (confering TTX and STX resistance), and an R1648H substitution (homologous to a mutation seen in human patients with Generalized Epilepsy with Febrile Seizures Plus). Two lines were generated, RH5 and RH9. Line RH9 had the highest level of transgene expression. (J:150454)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:150454 Tang B, et al., A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis. 2009 Jul;35(1):91-102
• All: 1 reference(s)