Tg(Kera-PITX2*A)BHjal
Transgene Detail

Summary

• Symbol: Tg(Kera-PITX2*A)BHjal
• Name: transgene insertion B, Tord Hjalt
• MGI ID: MGI:3851245
• Synonyms: Ktcn-PITX2
• Transgene: Tg(Kera-PITX2*A)BHjal Location: unknown
• Alliance: Tg(Kera-PITX2*A)BHjal page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Kera-PITX2*A)BHjal expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PITX2 (5308)

  Pitx2

  (MGI:109340)

• Mutation details: A transgenic construct containing cDNA for the human paired-like homeodomain 2, human, PITX2A, isoform under the control of the mouse keratocan ( Kera) promoter, and rabbit beta-globin polyA signal sequences was injected into fertilized CBAB6F2 mouse eggs. Numerous founders were obtained. In line B, multiple copies were found to be integrated on chromosome 12B3. Lines A and B display identical phenotypes. (J:93634)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93634 Holmberg J, et al., PITX2 gain-of-function in rieger syndrome eye model. Am J Pathol. 2004 Nov;165(5):1633-41
• All: 2 reference(s)