Tg(tetO-HTT*94Q,-lacZ)1Rhn
Transgene Detail

Summary

• Symbol: Tg(tetO-HTT*94Q,-lacZ)1Rhn
• Name: transgene insertion 1, Rene Hen
• MGI ID: MGI:3851440
• Synonyms: BiTetO
• Transgene: Tg(tetO-HTT*94Q,-lacZ)1Rhn Location: unknown
• Alliance: Tg(tetO-HTT*94Q,-lacZ)1Rhn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-HTT*94Q,-lacZ)1Rhn expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  mouse

  Htt (MGI:96067)

  human

  HTT (3064)

  Htt	(MGI:96067)

  The gene is a human/mouse chimera.

• Mutation details: The tetO promoter was used to drive conditional, bidirectional expression of a nuclear-localized lacZ and a mouse/human chimera of the gene containing an expansion of the CAG trinucleotide repeats in exon 1 to 94 repeats. No line information was given. (J:61490)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:61490 Yamamoto A, et al., Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell. 2000 Mar 31;101(1):57-66
• All: 10 reference(s)