Tg(Ckm-Ppargc1b)T37Brsp
Transgene Detail

Summary

• Symbol: Tg(Ckm-Ppargc1b)T37Brsp
• Name: transgene insertion T37, Bruce M Spiegelman
• MGI ID: MGI:4354127
• Synonyms: MCK-PGC-1b, PGC-1b
• Transgene: Tg(Ckm-Ppargc1b)T37Brsp Location: unknown
• Alliance: Tg(Ckm-Ppargc1b)T37Brsp page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Ppargc1b)T37Brsp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppargc1b (MGI:2444934)

• Mutation details: A transgenic construct containing the complete mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta gene cDNA, the 4.8kb mouse muscle creatine kinase promoter and the human growth hormone polyadenylation site was injected into fertilized FVB mouse eggs. Three lines were generated. Founder line T37 was subsequently established. Expression of Ppargc1b mRNA is increased 10-fold in the quadriceps, and transgene expression is higher in 'white', glycolytic muscle (EDL, quadriceps, gastrocnemius) than in 'red', oxidative muscle (soleus, heart). (J:118258)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:118258 Arany Z, et al., The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007 Jan;5(1):35-46
• All: 4 reference(s)