Tg(Prnp*A116V*M128V)1309Jama
Transgene Detail

Summary

• Symbol: Tg(Prnp*A116V*M128V)1309Jama
• Name: transgene insertion 1309, James A Mastrianni
• MGI ID: MGI:4356192
• Synonyms: Tg(A116V)
• Transgene: Tg(Prnp*A116V*M128V)1309Jama Location: unknown
• Alliance: Tg(Prnp*A116V*M128V)1309Jama page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:151934
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*A116V*M128V)1309Jama expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: Nucleotide substitutions in the mouse gene result in the amino acid substitutions of valine for alanine at position 116 (A117V) and valine for methionine at position 128 (M128V). These mutations mimic corresponding mutations (A116V and 129V) in the human gene in patients with Gerstmann-Straussler-Scheinker syndrome. This transgene was injected into Prnp^tm1Cwe containing oocytes and one line was examined (line 1309). (J:151934)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:151934 Yang W, et al., A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP. J Neurosci. 2009 Aug 12;29(32):10072-80
• All: 4 reference(s)