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Tg(CD2-Ccdc86)1Hfuj
Transgene Detail
Summary
Symbol: Tg(CD2-Ccdc86)1Hfuj
Name: transgene insertion 1, Hodaka Fujii
MGI ID: MGI:4356279
Synonyms: Cyclon-Tg, HA-Cyclon
Transgene: Tg(CD2-Ccdc86)1Hfuj  Location: unknown  
Alliance: Tg(CD2-Ccdc86)1Hfuj page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD2-Ccdc86)1Hfuj expresses 1 gene
 
Tg(CD2-Ccdc86)1Hfuj expression driven by 1 gene
 
Mutation detailsMurine Ccdc86 coding sequence was inserted into the VA-hCD2 expression vector and the resulting transgene was injected into the pronuclei of fertilized eggs. mRNA and protein expression was confirmed by RT-PCR and immunoblot analysis of splenocytes. Expression level of the transgene product was 1.7 and 1.49 fold greater than endogenous protein in CD4+ or CD8+ T cells. The n-terminus of the protein product is tagged by an HA epitope tag. (J:151722)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:151722 Saint Fleur S, et al., Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory