Tg(Pbsn-ERG*)1Vv
Transgene Detail

Summary

• Symbol: Tg(Pbsn-ERG*)1Vv
• Name: transgene insertion 1, Valeri Vasioukhin
• MGI ID: MGI:4358243
• Synonyms: deltaN-ERG
• Transgene: Tg(Pbsn-ERG*)1Vv Location: unknown
• Alliance: Tg(Pbsn-ERG*)1Vv page

Transgene origin

• Strain of Origin: C57BL/6J x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-ERG*)1Vv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERG (2078)

  Erg	(MGI:95415)

• Mutation details: A transgenic construct containing a rat probasin promoter (Pbsn), beta globin intron, a truncated N-terminal human avian erythroblastosis virus E-26 (v-ets) oncogene related (ERG) cDNA and poly(A) sequences was injected into C57BL/6 X CBA fertilized embryos. Two mouse lines were generated. Founder line 1 had significantly higher levels of the mutant ERG transcript. Truncated ERG protein were higher in Western blots of the ventral prostate with significantly lower levels in dorsolateral and anterior lobes. (J:131932)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-ERG*)1Vv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131932 Klezovitch O, et al., A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2105-10
• All: 7 reference(s)