Lmr20 QTL Detail

Summary

• Symbol
  Lmr20
• Name
  leishmaniasis resistance 20

• Feature Type
  QTL
• IDs
  MGI:4360532
• Candidate Genes
  8 Genes

Location &
Maps

• Sequence Map
  Chr1:175468817-175468938 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 1

  Phenotypes 1
• Earliest
  J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33

Candidate Genes for Lmr20:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Fcer1a	Chr1:173048851-173054781 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Fcer1g	Chr1:171057141-171061918 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Fcgr2b	Chr1:170786186-170804116 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Ifi201	Chr1, Syntenic	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Ifi202a	Chr1:173790141-173859357 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Ifi203	Chr1:173747973-173770238 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Ifi204	Chr1:173574859-173594509 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Tgfb2	Chr1:186354989-186438186 (-)	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].