Lmr22 QTL Detail

Summary

• Symbol
  Lmr22
• Name
  leishmaniasis resistance 22

• Feature Type
  QTL
• IDs
  MGI:4360534
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr12:5418440-5418579 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 1

  Phenotypes 1
• Earliest
  J:152405 Kurey I, et al., Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009 Sep;61(9):619-33

Candidate Genes for Lmr22:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Adam17	Chr12:21373510-21423633 (-)	J:152405	A potential candidated gene mapping near the Lmr22 QTL which mapped with D12Mit37 at 1.0 cM on Chromosome 12 of CcS11/Dem in this map study is Adam17, a disintegrin and metallopeptidase domain 17 mapping to 3.0 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr22 QTL are: Cinda2, cytokine induced activation 2 at 1.0 cM; and Cd4ts5, CD4 T cell subset 5 at 6.0 cM. [Table 10.]