Tg(RBP3-ELOVL4*)2Kzh
Transgene Detail

Summary

• Symbol: Tg(RBP3-ELOVL4*)2Kzh
• Name: transgene insertion 2, Kang Zhang
• MGI ID: MGI:4360792
• Synonyms: tg2, TG(mutELOVL4)2
• Transgene: Tg(RBP3-ELOVL4*)2Kzh Location: unknown
• Alliance: Tg(RBP3-ELOVL4*)2Kzh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RBP3-ELOVL4*)2Kzh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ELOVL4 (6785)

  Elovl4

  (MGI:1933331)

• Mutation details: The human promoter was used to drive photoreceptor-specific expression of a human cDNA with a deletion of AACTT at position 790 to 794 found in patients with Stargardt-like macular dystrophy. Three lines were created (lines 1, 2, and 3) with 0.6, 3.3, and 5.3 times the level of endogenous gene expression, respectively. (J:97173)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97173 Karan G, et al., Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4164-9
• All: 10 reference(s)