Tg(tetO-PLAGL2)P3Ysy
Transgene Detail

Summary

• Symbol: Tg(tetO-PLAGL2)P3Ysy
• Name: transgene insertion P3, Yih-Sheng Yang
• MGI ID: MGI:4360887
• Synonyms: (tetO)7CMV-PLAGL2
• Transgene: Tg(tetO-PLAGL2)P3Ysy Location: unknown
• Alliance: Tg(tetO-PLAGL2)P3Ysy page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-PLAGL2)P3Ysy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLAGL2 (5326)

  Plagl2

  (MGI:1933165)

• Mutation details: A CMV promoter with 7 tetO sites was used to drive inducible the human cDNA. Four founders were generated (P1, P2, P3, and P4) with 4, 10, 26, and 180 copies of the transgene, respectively. P3 was selected as the representative line. (J:152422)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152422 Yang YS, et al., PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol. 2009 Sep;297(3):L455-66
• All: 1 reference(s)