Tg(Col2a1-rtTA,tetO-COMP)1Jath
Transgene Detail

Summary

• Symbol: Tg(Col2a1-rtTA,tetO-COMP)1Jath
• Name: transgene insertion 1, Jacqueline Hecht
• MGI ID: MGI:4361027
• Synonyms: Tg(Col2a1-rtTA,TRE-COMP)1Jath, WT-COMP
• Transgene: Tg(Col2a1-rtTA,tetO-COMP)1Jath Location: unknown
• Alliance: Tg(Col2a1-rtTA,tetO-COMP)1Jath page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Col2a1-rtTA,tetO-COMP)1Jath expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHI3L1 (1116)

  Chi3l1

  (MGI:1340899)

• Mutation details: Bigenic mice contain a rtTA driven by the mouse Col2a1 promoter and human COMP driven by the tetO promoter. No line information was given. (J:152756)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152756 Posey KL, et al., An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype. Am J Pathol. 2009 Oct;175(4):1555-63
• All: 3 reference(s)