Tg(Col2a1-rtTA,tetO-COMP*)2Jath
Transgene Detail

Summary

• Symbol: Tg(Col2a1-rtTA,tetO-COMP*)2Jath
• Name: transgene insertion 2, Jacqueline Hecht
• MGI ID: MGI:4361028
• Synonyms: MT-COMP, Tg(Col2a1-rtTA,TRE-COMP*)2Jath
• Transgene: Tg(Col2a1-rtTA,tetO-COMP*)2Jath Location: unknown
• Alliance: Tg(Col2a1-rtTA,tetO-COMP*)2Jath page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Col2a1-rtTA,tetO-COMP*)2Jath expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COMP (1311)

  Comp	(MGI:88469)

• Mutation details: Bigenic mice contain a rtTA driven by the mouse Col2a1 promoter and human COMP, with the deletion del469D found in patients with pseudoachondroplasia, driven by the tetO promoter. Three lines were generated (no line names given). (J:152756)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152756 Posey KL, et al., An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype. Am J Pathol. 2009 Oct;175(4):1555-63
• All: 6 reference(s)