Del(15Krt7-Krt18)1Tmm Cytogenetic Marker Detail

Summary

• Symbol
  Del(15Krt7-Krt18)1Tmm
• Name
  deletion, Chr 15, Thomas M Magin 1
• Synonyms
  Del(15Krt80-Krt18)1Tmm, KtyII^-

• Feature Type
  chromosomal deletion
• IDs
  MGI:4410572

Location &
Maps

• Sequence Map
  Chr15:101246196-101940461 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• Changed name to reflect the fact that the clone determining the 5' edge of the deletion is inserted between Krt80 and Krt7, so Krt80 is not deleted (though its promoter may be).

• Genetic Map
  Chromosome 15, Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 1 genetic background
  3 phenotypes from multigenic genotypes
  2 images
  21 phenotype references
  

• All Mutations and Alleles
  2
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  1 involving Del(15Krt7-Krt18)1Tmm
• Find Mice (IMSR)
  0 strains or lines available

Deletion of the genes in this region results in embryonic lethality during organogenesis; however, embryonic and extra-embryonic epithelia remain intact.

References

• Summaries
  All 22

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27