Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
• Name: transgene insertion 152H, Laurence Ozmen
• MGI ID: MGI:4412048
• Synonyms: B6.152H, PS2APP
• Transgene: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Location: unknown
• Alliance: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish mutations.

  human

  PSEN2 (5664)

  Psen2

  (MGI:109284)

• Mutation details: A construct containing a Thy1 promoter driving expression of the human APP with the Swedish familial Alzheimer disease mutations (K670N, M671L) was co-injected with a construct containing the Prnp promoter driving the expression of human PSEN2 with the familial Alzheimer disease mutation N141I. Line 152H was used in subsequent experiments. (J:88193, J:154969)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:154969 Ozmen L, et al., Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice. Neurodegener Dis. 2009;6(1-2):29-36
• All: 29 reference(s)