Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
Transgene Detail

Summary

• Symbol: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
• Name: transgene insertion 10, TaconicArtemis
• MGI ID: MGI:4417910
• Synonyms: ARTE10, Tg(Thy1-PSEN1*M146V/Thy1-APP*swe)10Arte
• Transgene: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte Location: unknown
• Alliance: Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte page

Onset and development of plaques in Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish mutations.

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

• Mutation details: This transgene is composed of two constructs containing the Thy1 promoter driving expression of human PSEN1 with the amino acid substitution of valine for methionine at position 146 and human APP with the Swedish familial Alzheimer disease mutation (K670N, M671L). Line 10 (also known as 10-279) was selected as the representative line. (J:155410)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155410 Willuweit A, et al., Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS One. 2009;4(11):e7931
• All: 5 reference(s)