Tg(Thy1-APPSweArc)BLngn
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSweArc)BLngn
• Name: transgene insertion B, Lars Nilsson
• MGI ID: MGI:4420229
• Synonyms: tg-APPArcSwe, tgAPP-ArcSwe, tg-ArcSwe
• Transgene: Tg(Thy1-APPSweArc)BLngn Location: unknown
• Alliance: Tg(Thy1-APPSweArc)BLngn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSweArc)BLngn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A human amyloid beta (A4) precursor protein cDNA sequence (APP695) was altered to include the APP KM670/671NL (Swedish) + E693G (Arctic) Familial Alzheimer's Disease (FAD) mutations. The resultant APPArcSwe construct was then placed downstream of the mouse thymus cell antigen 1, theta [Thy1] promoter (via insertion into the ATG start site in exon 2 of the mouse Thy1 locus in the Thy-1323-cassette). The resulting transgene was microinjected into (C57BL/6xCBA)F1 pronuclear oocytes. Mice from founder line B had both Swedish and Arctic mutations; these tg-APP^ArcSwe transgenic mice were subsequently backcrossed to C57BL/6JBomTac. (J:105265)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105265 Lord A, et al., The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging. 2006 Jan;27(1):67-77
• All: 12 reference(s)