Tg(Htt-ATXN3*148Q)3746Thsc
Transgene Detail

Summary

• Symbol: Tg(Htt-ATXN3*148Q)3746Thsc
• Name: transgene insertion 3746, Thorsten Schmidt
• MGI ID: MGI:4429385
• Synonyms: HDPromMJD148
• Transgene: Tg(Htt-ATXN3*148Q)3746Thsc Location: unknown
• Alliance: Tg(Htt-ATXN3*148Q)3746Thsc page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Htt-ATXN3*148Q)3746Thsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The rat promoter drives whole brain expression of the human cDNA for isoform C. The polyglutamine trinucleotide CAG repeat was expanded to 148 copies (148Q). One line, 3746, was created. (J:156912)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:156912 Boy J, et al., A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats. Neurobiol Dis. 2010 Feb;37(2):284-293
• All: 2 reference(s)