Tg(tetO-Ppargc1a)1Dpk
Transgene Detail

Summary

• Symbol: Tg(tetO-Ppargc1a)1Dpk
• Name: transgene insertion 1, Daniel P Kelly
• MGI ID: MGI:4429485
• Synonyms: TRE-PGC-1 alpha
• Transgene: Tg(tetO-Ppargc1a)1Dpk Location: unknown
• Alliance: Tg(tetO-Ppargc1a)1Dpk page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Ppargc1a)1Dpk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppargc1a (MGI:1342774)

• Mutation details: Mouse Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) cDNA with a C-terminal myc-his tag was placed under the control of the tetracycline operator (tetO). (J:96614)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96614 Russell LK, et al., Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 5;94(4):525-33
• All: 12 reference(s)