Is(14)2Rdf Cytogenetic Marker Detail

Summary

• Symbol
  Is(14)2Rdf
• Name
  insertion, Chr 14, Riccardo Dalla-Favera 2

• Feature Type
  insertion
• IDs
  MGI:4437004

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 14, Syntenic

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  3 strains or lines available

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 2
• Earliest
  J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
• Latest
  J:332089 Ten Hacken E, et al., In vivo modeling of CLL transformation to Richter's syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities. Blood Cancer Discov. 2022 Dec 5;