Tg(GFAP-HTT*160Q)31Xjl
Transgene Detail

Summary

• Symbol: Tg(GFAP-HTT*160Q)31Xjl
• Name: transgene insertion 31, Xiao-Jiang Li
• MGI ID: MGI:4437299
• Synonyms: GFAP-HD, Htt-160Q
• Transgene: Tg(GFAP-HTT*160Q)31Xjl Location: unknown
• Alliance: Tg(GFAP-HTT*160Q)31Xjl page

Transgene origin

• Strain of Origin: FVB/NCrl

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP-HTT*160Q)31Xjl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The GFAP-HD transgene was designed containing 208 aa of N-terminal human huntingtin (HTT) gene, containing 160 glutamine residues (160Q), driven by the human glial fibrillary acidic protein (GFAP) promoter, followed by a mouse protamine-1 (MP-1) polyadenylation (polyA) signal. (J:156460)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:156460 Bradford J, et al., Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22480-5
• All: 2 reference(s)