Tg(Pkd1)26Mtru
Transgene Detail

Summary

• Symbol: Tg(Pkd1)26Mtru
• Name: transgene insertion 26, Marie Trudel
• MGI ID: MGI:4437718
• Synonyms: Pkd1TAG
• Transgene: Tg(Pkd1)26Mtru Location: unknown
• Alliance: Tg(Pkd1)26Mtru page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pkd1)26Mtru expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pkd1 (MGI:97603)

• Mutation details: A BAC was modifed to insert a silent mutation in exon 10 to act as a tag (G -> A). A second modification removed 34.5 kb of the Tsc2 gene from the BAC. Three lines were created (lines 6, 18, and 26) with 2 to 15 copies of the transgene (2, 6, and 15, respectively). (J:157952)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:157952 Kurbegovic A, et al., Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes. Hum Mol Genet. 2010 Apr 1;19(7):1174-89
• All: 2 reference(s)