Tg(Pkd1)26Mtru
Transgene Detail

Summary

• Symbol: Tg(Pkd1)26Mtru
• Name: transgene insertion 26, Marie Trudel
• MGI ID: MGI:4437718
• Synonyms: Pkd1TAG
• Transgene: Tg(Pkd1)26Mtru Location: unknown
• Alliance: Tg(Pkd1)26Mtru page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pkd1)26Mtru expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pkd1 (MGI:97603)

• Mutation details: A BAC was modifed to insert a silent mutation in exon 10 to act as a tag (G -> A). A second modification removed 34.5 kb of the Tsc2 gene from the BAC. Three lines were created (lines 6, 18, and 26) with 2 to 15 copies of the transgene (2, 6, and 15, respectively). (J:157952)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Pkd1)26Mtru/0	involves: C57BL/6J * CBA/J

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
cardiovascular system	√
abnormal myocardium layer morphology	√
thick interventricular septum	√
increased heart weight	√
cardiac hypertrophy	√
heart left ventricle hypertrophy	√
abnormal aortic valve cusp morphology	√
aortic valve stenosis	√
calcified aortic valve	√
thick ventricular wall	√
cardiac fibrosis	√
dilated heart	√
dystrophic cardiac calcinosis	√
aneurysm	√
increased cardiac output	√
increased cardiac stroke volume	√
subarachnoid hemorrhage	√
hypertension	√
cellular	√
increased kidney cell proliferation	√
increased hepatocyte proliferation	√
craniofacial	√
abnormal sagittal suture morphology	√
growth/size/body	√
increased heart weight	√
cardiac hypertrophy	√
heart left ventricle hypertrophy	√
kidney cyst	√
kidney cortex cyst	√
kidney medulla cyst	√
liver cyst	√
hematopoietic system	√
decreased hematocrit	√
homeostasis/metabolism	√
increased blood osmolality	√
increased circulating phosphate level	√
increased circulating sodium level	√
decreased urine protein level	√
increased urine protein level	√
hematuria	√
liver/biliary system	√
increased hepatocyte proliferation	√
liver cyst	√
liver fibrosis	√
mortality/aging	√
premature death	√
muscle	√
abnormal myocardium layer morphology	√
heart left ventricle hypertrophy	√
nervous system	√
subarachnoid hemorrhage	√
abnormal cerebellum development	√
hydrocephaly	√
dilated brain ventricle	√
small cerebellum	√
renal/urinary system	√
increased kidney cell proliferation	√
kidney cyst	√
kidney cortex cyst	√
kidney medulla cyst	√
decreased urine protein level	√
increased urine protein level	√
hematuria	√
glomerulosclerosis	√
abnormal renal tubule epithelium morphology	√
kidney epithelium hyperplasia	√
renal interstitial fibrosis	√
dilated renal tubule	√
renal cast	√
nephrocalcinosis	√
nephrolithiasis	√
pale kidney	√
polyuria	√
skeleton	√
abnormal sagittal suture morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
autosomal recessive polycystic kidney disease IDs autosomal recessive polycystic kidney disease       DOID:0110861 ICD10CM:Q61.1 ICD9CM:753.14 MESH:D017044 NCI:C84579 ORDO:731 UMLS_CUI:C0085548 Close	√

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:157952 Kurbegovic A, et al., Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes. Hum Mol Genet. 2010 Apr 1;19(7):1174-89
• All: 2 reference(s)