Tg(Fabp4-LEP)F8Ffc
Transgene Detail

Summary

• Symbol: Tg(Fabp4-LEP)F8Ffc
• Name: transgene insertion F8, Farid F Chehab
• MGI ID: MGI:4437889
• Synonyms: LepTg
• Transgene: Tg(Fabp4-LEP)F8Ffc Location: unknown
• Alliance: Tg(Fabp4-LEP)F8Ffc page

Transgene origin

• Strain of Origin: C57BL/6J x DBA/2J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-LEP)F8Ffc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LEP (3952)

  Lep	(MGI:104663)

• Mutation details: The Fabp4-LEP transgene was designed with the mouse aP2 promoter driving the expression of the human leptin (LEP) gene. Fabp4-LEP consists of, from 5' to 3', an aP2 promoter/enhancer, rabbit beta-globin, human leptin cDNA, and human growth hormone (hGH) polyadenylation (polyA) signal. One line, F8, was generated. Expression of the transgene was detected in brown adipose tissue, all white adipose tissue depots and in macrophages. (J:67311)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67311 Qiu J, et al., Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age. Endocrinology. 2001 Jan;142(1):348-58
• All: 4 reference(s)