Tg(HTT*97Q)LXwy
Transgene Detail

Summary

• Symbol: Tg(HTT*97Q)LXwy
• Name: transgene insertion L, X William Yang
• MGI ID: MGI:4438228
• Synonyms: BACHD-L
• Transgene: Tg(HTT*97Q)LXwy Location: unknown
• Alliance: Tg(HTT*97Q)LXwy page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HTT*97Q)LXwy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The 240 kb human bacterial artificial chromosome BAC(RP11-866L6), containing the entire 170 kb human Huntingtin (htt) genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences, was modified by replacing the human htt exon 1 with a loxP-flanked human mutant htt exon 1 sequence (containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine (polyQ) stretch). Two lines were created (line I and L) that exhibit the same phenotype. (J:137345)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:137345 Gray M, et al., Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci. 2008 Jun 11;28(24):6182-95
• All: 8 reference(s)