Tg(CAG-lacZ,-SV40)#Bcv
Transgene Detail

Summary

• Symbol: Tg(CAG-lacZ,-SV40)#Bcv
• Name: transgene insertion, Barbara C Vanderhyden
• MGI ID: MGI:4439280
• Synonyms: tgCAG-LS-TAg
• Transgene: Tg(CAG-lacZ,-SV40)#Bcv Location: unknown
• Alliance: Tg(CAG-lacZ,-SV40)#Bcv page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The construct contains the early region of SV40 TAg, a beta-geo gene (a fusion of beta-galactosidase and neomycin phosphotransferase genes) expressed from the cytomegalovirus (CMV) early enhancer/chicken beta-actin (CAG) promoter. The beta-geo gene and three downstream polyA signals (3xpolyA) are flanked by loxP sites. Exposure to Cre recombinase results in the deletion of the beta-geo/3xpolyA cassette leading to the TAg expression. Two lines showed reproducible expression of beta-gal in the ovarian surface epithelium (OSE). Of these two lines, only one was found to express SV40 TAg in the OSE after the intrabursal administration of adenovirus expressing Cre recombinase. No line number was given. (J:158388)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158388 Laviolette LA, et al., 17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer. Endocrinology. 2010 Mar;151(3):929-38
• All: 3 reference(s)