Trac MGI Mouse Gene Detail - MGI:4439838 - T cell receptor alpha constant

Symbol

Trac
Name

T cell receptor alpha constant
Synonyms

Gm16914

Feature Type

gene segment
IDs

MGI:4439838
NCBI Gene: 100101484
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr14:54457978-54461655 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.70 cM
Mapping Data

14 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_4439838	gene segment	Chr14:54457978-54461663 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0002422	gene segment	Chr14:48148844-48152520 (+)
A/J	MGP_AJ_G0002397	gene segment	Chr14:47240801-47244477 (+)
AKR/J	MGP_AKRJ_G0002383	gene segment	Chr14:48949783-48953459 (+)
BALB/cJ	MGP_BALBcJ_G0002392	gene segment	Chr14:47209574-47216213 (+)
C3H/HeJ	MGP_C3HHeJ_G0002370	gene segment	Chr14:48630908-48634692 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0002518	gene segment	Chr14:50616802-50622093 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002120	gene segment	Chr14:45653430-45657119 (+)
CAST/EiJ	MGP_CASTEiJ_G0002332	gene segment	Chr14:44862756-44866430 (+)
CBA/J	MGP_CBAJ_G0002362	gene segment	Chr14:52108479-52112158 (+)
DBA/2J	MGP_DBA2J_G0002368	gene segment	Chr14:46985030-46988741 (+)
FVB/NJ	MGP_FVBNJ_G0002380	gene segment	Chr14:46439267-46443264 (+)
LP/J	MGP_LPJ_G0002422	gene segment	Chr14:49180064-49183835 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002350	gene segment	Chr14:51549958-51554023 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002512	gene segment	Chr14:48131550-48135225 (+)
PWK/PhJ	MGP_PWKPhJ_G0002293	gene segment	Chr14:43508755-43513087 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0002246	gene segment	Chr14:44109901-44115269 (+)
WSB/EiJ	MGP_WSBEiJ_G0002362	gene segment	Chr14:48423310-48428096 (+)

Human Ortholog

TRA, T cell receptor alpha locus

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRA, T cell receptor alpha locus
Synonyms

IMD7, TCRA, TRA@
Links

HGNC:12027

NCBI Gene ID: 6955

UniProt: P0DSE1, P0DTU3
Chr Location

14q11.2; chr14:21621904-22552132 (+) GRCh38

Human Ortholog

TRAC, T cell receptor alpha constant
Synonyms

IMD7, TCRA, TRA, TRCA
Links

HGNC:12029

NCBI Gene ID: 28755

UniProt: P01848
Chr Location

14q11.2; chr14:22547506-22552156 (+) GRCh38

MGI Vertebrate Homology

Trac stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: TRA, TRAC
Gene Tree

Trac

Diseases

1 with human TRAC associations

				Human Disease	Mouse Models
				immunodeficiency 7 IDs immunodeficiency 7 DOID:0111977 OMIM:615387 ORDO:397959 UMLS_CUI:C3809332

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

2
Targeted

1
Transgenic

3
Genomic Mutations

1 involving Trac
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

46
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trac

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All Sequences

26
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000076928 (Evidence)
NCBI Gene

100101484

Representative Sequences				Length	Strain/Species	Flank
	genomic	100101484	NCBI Gene Model \| MGI Sequence Detail	3678	C57BL/6J	± kb
	polypeptide	A0A991BQX6	UniProt \| EBI \| MGI Sequence Detail	137	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR015370 T-cell receptor alpha chain, constant domain

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All nucleic 93

Genomic 27

cDNA 61

Primer pair 1

Other 4

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MGD-MRK-14846, MGI:98554

Summaries

All 55

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 10
Earliest

J:7626 Chien Y, et al., A third type of murine T-cell receptor gene. Nature. 1984 Nov 1-7;312(5989):31-5
Latest

J:337059 Iwanami N, et al., Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR alpha chain of iNKT cells. Nat Commun. 2023 Jun 20;14(1):3645

TSS for Trac:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125597	Chr14:54456431-54456442 (+)	-1,541 bp
Tssr125598	Chr14:54456487-54456496 (+)	-1,486 bp
Tssr125599	Chr14:54458023-54458042 (+)	55 bp
Tssr125600	Chr14:54458153-54458167 (+)	182 bp
Tssr125601	Chr14:54459694-54459713 (+)	1,726 bp
Tssr125602	Chr14:54459821-54459831 (+)	1,848 bp
Tssr125603	Chr14:54460195-54460211 (+)	2,225 bp
Tssr125604	Chr14:54460231-54460246 (+)	2,261 bp
Tssr125605	Chr14:54460265-54460276 (+)	2,293 bp
Tssr125606	Chr14:54460295-54460307 (+)	2,323 bp
Tssr125607	Chr14:54461172-54461190 (+)	3,203 bp
Tssr125608	Chr14:54461419-54461429 (+)	3,446 bp
Tssr125609	Chr14:54461490-54461504 (+)	3,519 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24